Associate Research Professor, Chemistry
office: MSB 239
phone: (256) 824-6278
fax: (256) 824-6349
email: Liqing Chen
Résumé
Research Interests
X-ray crystallography; structural biology; structure-based drug design, lead discovery and optimization; structural genomics.
Publications
Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity. Yujun Wang, Li Qiu, Hilary Ranson, Nongkran Lumjuan, Janet Hemingway, William N. Setzer, Edward J. Meehan and Liqing Chen, J. Struct. Biol. 164, 228-235 (2008).
Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. Xiaomin Hou, Edward J. Meehan, Jieming Xie, Mingdong Huang, Minghuang Chen and Liqing Chen, J. Struct. Biol. 164, 81-87 (2008).
A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. Lili Zhu, Feng Yang, Liqing Chen, Edward J. Meehan and Mingdong Huang, J. Struct. Biol. 162, 40-49 (2008).
1,7-Dihydroxy-2,3,4-trimethoxy-9H-xanthen-9-one monohydrate from Halenia elliptica. Peizhong Yu, Xiaojuan Shen, Changqi Hu, Edward J. Meehan and Liqing Chen, Acta Cryst. E64, o651-o652 (2008).
Crystallization and preliminary crystallographic analysis of beta-trichosanthin, an isoform of trichosanthin from the root tuber of Trichosanthe kirilowii. Xiaomin Hou, Minghuang Chen, Qi Peng, Liqing Chen, Edward J. Meehan and Mingdong Huang, Chinese J. Struct. Chem. 26, 1303-1307 (2007).
X-ray sequence and crystal structure of luffaculin I, a novel type I ribosome-inactivating protein. Xiaomin Hou, Minghuang Chen, Liqing Chen, Edward J. Meehan, Jieming Xie and Mingdong Huang, BMC Structural Biology 7:29 (2007).
X-ray structure and antioxidant activity of salidroside, a phenylethanoid glycoside. Peizhong Yu, Changqi Hu, Edward J. Meehan and Liqing Chen, Chemistry & Biodiversity 4, 508-513 (2007).
An-anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope. Yongdong Li, Graham Parry, Liqing Chen, Jennifer A. Callahan, David E. Shaw, Edward J. Meehan, Andrew P. Mazar and Mingdong Huang, J. Mol. Biol. 365, 1117-1129 (2007).
Crystallization and preliminary crystallographic studies of Luffaculin 1, a ribosome-inactivating protein from the seeds of Luffa Acutangula. Xaio-Min Hou, Ming-Huang Chen, Jie-Ming Xie, Xiao-Ming Ye, Geng-Xiang Zhao, Feng Yang, Li-Qing Chen, Ming-Dong Huang, Chinese J. Struct. Chem. 25, 1035-1038 (2006).
Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. Liqing Chen, Yujun Wang, David Wells, Diana Toh, Hunt Harold, Jing Zhou, Enrico DiGiammarino and Edward J. Meehan, Acta Crystallographica F62, 844-848 (2006).
An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+. Yijian Rao, Chuanbing Bian, Cai Yuan, Yongdong Li, Liqing Chen, Xiaoming Ye, Zixiang Huang, Mingdong Huang, Biochem. & Biophys. Res. Commun. 348, 908-915 (2006).
Structure of human urokinase plasminogen activator in complex with its receptor. Qing Huai, Andrew P. Mazar, Alice Kuo, Graham C. Parry, David E. Shaw, Jennifer Callahan, Yongdong Li, Cai Yuan, Chuanbing Bian, Liqing Chen, Bruce Furie, Barbara C. Furie, Douglas B. Cines, Mingdong Huang, Science 311, 656-659 (2006).
Mutation of a conserved tryptophan in the chitin-binding cleft of S. marcescens chitinase A enhances transglycosylation. Nathan N. Aronson, Jr., Brian A. Halloran, Mikhail F. Alexyev, Xiaoyin E. Zhou, Yujun Wang, Edward J. Meehan & Liqing Chen, Biosci., Biotechnol., and Biochem. 70, 243-251 (2006).
Optimization of crystals of an inhibitory antibody of urokinase plasminogen activator receptor (uPAR) with hydrogen peroxide and low protein concentration. Yongdong Li, Xiaoli Shi, Graham Parry, Liqing Chen, Jennifer A. Callahan, Andrew P. Mazar & Mingdong Huang, Protein Pept. Lett. 12, 655-658 (2005).
High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target. Liqing Chen, Enrico DiGiammarino, Xiaoyin E. Zhou, Yujun Wang, Diana Toh, Thomas W. Hodge & Edward J. Meehan, J. Biol. Chem. 279, 40204-40208 (2004).
The hyperthermophile protein Sso10a is a dimer of winged helix DNA-binding domains linked by an antiparallel coiled coil rod.Liqing Chen,Li-Rong Chen, Xiaoyin E. Zhou, Yujun Wang, Mebrahtu Kahsai, Andrew T. Clark, Stephen P. Edmondson, Zhi-Jie Liu, John P. Rose, Bi-Cheng Wang, Edward J. Meehan & John W. Shriver, J. Mol. Biol. 341, 73-91 (2004).
Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain. Shanyun Lu, Jindrich Symmersky, Songlin Li, Mike Carson, Liqing Chen, Edward Meehan & Ming Luo, Proteins: Structure, Function, and Bioinfomatics 56, 384-386 (2004).
Crystal structure of Type IIE restriction endonuclease EcoRII reveals an autoinhibition mechanism by a novel effector-binding fold. Xiaoyin E. Zhou, Yujun Wang, Monika Reuter, Merlind Mücke, Detlev H. Krüger, Edward J. Meehan & Liqing Chen, J. Mol. Biol. 335, 307-319 (2004).
Crystal structure of an insect delta-class glutathione S-transferase from a DDT- resistant strain of the malaria vector Anopheles gambiae. Liqing Chen, Pamela R. Hall, Xiaoyin E. Zhou, Hilary Ranson, Janet Hemingway & Edward J. Meehan, Acta Crystallographica D59, 2211-2217 (2003).
A single mutation of restriction endonuclease EcoRII led to a new crystal form that diffracts to 2.1 [A] resolution. Xiaoyin E. Zhou, Yujun Wang, Monika Reuter, Petra Mackeldanz, Detlev H. Kruger, Edward J. Meehan & Liqing Chen, Acta Crystallographica D59, 910-912 (2003).
Molecular replacement studies of cucurmosin from cucurbita moschata: structure homology with trichosanthin. Shi Xiao-Li, Edward X. Zhou, Ye Xiao-Ming, Edward J. Meehan, Chen Ming-Huang & Liqing Chen, Chinese J. Struc. Chem. 22, 165-168 (2003).
A new crystal form of restriction endonuclease EcoRII that diffracts to 2.8 [A] resolution. Edward X. Zhou, Monika Reuter, Edward J. Meehan & Liqing Chen. Acta Crystallographica D58, 1343-1345 (2002).
Crystallization and preliminary X-ray diffraction analysis of protein L-isoaspartyl O-methyltransferase from wheat germ. Michelle D. Amaral, Liqing Chen, Debasish Chattopadhyay, Craig D. Smith & Edward J. Meehan, Acta Crystallographica D57, 304-305 (2001).
Crystallization of agGST1-6, a recombinant glutathione S-transferase from a DDT-resistant strain of Anopheles gambiae. Pamela H. Roberts, Xiaoyin Zhou, Anna M. Holmes, Hilary Ranson, Graham Small, Janet Hemingway, Joseph D. Ng, Liqing Chen & Edward J. Meehan, Acta Crystallographica D57, 134-136 (2001).
Triterpenoid constituents in the bark of Balanops australiana. William N. Setzer, Mary C. Setzer, R. Lynton Peppers, Michael B. McFerrin, Edward J. Meehan, Liqing Chen, Robert B. Bates, Pichaya Nakkiew and Betsy R. Jackes, Aust. J. Chem. 53, 809-812 (2000).
Crystallization and preliminary X-ray diffraction analysis of restriction endonuclease EcoRII. Elisavetta A. Karpova, Edward Meehan, Marc L. Pusey & Liqing Chen, Acta Crystallographica D55, 1604-1605 (1999).
Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, North Queensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate. William N. Setzer, Mary C. Setzer, Robert B. Bates, Pichaya Nakkiew, Betsy R. Jackes, Liqing Chen, Michael B. McFerrin & Edward J. Meehan, Planta Medica 65(8), 747-749 (1999).
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Li Su, Liqing Chen, Martin Egli, James M. Berger & Alexander Rich, Nature Structural Biology 6(3), 285-292 (1999).
Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere. Li Cai, Liqing Chen, Sridharan Raghavan, Robert Ratliff, Robert Moyzis & Alexander Rich, Nucleic Acids Research 26(20), 4696-4705 (1998).
Energetics of the lattice: packing elements in crystals of four- stranded intercalated cytosine-rich DNA molecules. Imre Berger, Li Cai, Liqing Chen & Alexander Rich, Biopolymers: Nucl. Acid Sci. 44(3), 257-267 (1997).
3-D structure of the D153G mutant of E. coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity. Chris G. Dealwis, Liqing Chen, Cathy Brennan, Wlodek Mandecki & Cele Abad-Zapatero, Protein Engineering 8, 865-871 (1995).
Crystal structure of a four-stranded intercalated DNA: d(C4). Liqing Chen, Li Cai, Xiaohua Zhang & Alexander Rich, Biochemistry 33, 13540-13546 (1994)
Crystal structure of recombinant human platelet factor 4. Xiaohua Zhang, Liqing Chen, Daniel Bancroft, C. K. Lai & Theodore Maione, Biochemistry 33, 8361-8366 (1994).
Three-dimensional structure of a mutant (Asp101->Ser) of E. coli alkaline phosphatase with higher catalytic efficiency. Liqing Chen, David J. Neidhart, William M. Kohlbrenner, Wlodek Mandecki, Sean Bell, Janusz Sowadski & Cele Abad-Zapatero, Protein Engineering 5, 605-610 (1992).
The structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor. Liqing Chen, John W. Erickson, Timothy J. Rydel, Chang H. Park, David J. Neidhart, Jay Luly & Cele Abad-Zapatero, Acta Cryst. B48, 476-488 (1992).
Crystal structure of a bovine neurophysin-II dipeptide complex at 2.8A determined from the single-wavelength anomalous scattering signal of an incorporated iodine atom. Liqing Chen, John Rose, Esther Breslow, Daniel Yang, Wen-Rui Chang, William Furey, Jr., Martin Sax & Bi-Cheng Wang, Proc. Natl. Acad. Sci. U.S.A. 88, 4240- 4244 (1991).
A new crystal form of ricin-OR. Wen-rui Chang, Liqing Chen, John Rose, Chin Hsuan Wei, Leatrice Abrams, Martin Sax & Bi-Cheng Wang, Eur. J. Biochem. 180, 327-328 (1989).
Crystal structure of bis(n5-cyclopentadienyl-n6-tetrahydronaphthaleneiron(II)) dodecahydrododecaborate (C15H17Fe+)2B12H122-. Liqing Chen, Kezhen Pan, Lun Zhang & Peizhi Hu, Chinese J. Struc. Chem. 3(1), 1-4 (1984).
Crystal structure of bis(n5-cyclopentadienyl-n6-isopropylbenzene-iron(II)) dodecahydrododecaborate (C14H17Fe+)2B12H122-. Liqing Chen, Kezhen Pan, Lun Zhang & Peizhi Hu, Chinese J. Struc. Chem. 3(1), 5-8 (1984).
Crystal structure of bis(n5-cyclopentadienyl-1,3-propanediyl- bis(diphenylphosphine(-P,P')) nickel(II)) dodecahydrododecaborate (C5H5Ni(C6H5)2PC3H6P(C6H5)2+)2B12H122-. Liqing Chen, Kezhen Pan, Xinlan Chen & Lun Zhang, Chinese J. Struc. Chem. 3(2), 125-128 (1984)